Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1298390..1298615 Replicon chromosome
Accession NZ_AP026087
Organism Escherichia coli strain 8_140198

Toxin (Protein)


Gene name hokW Uniprot ID A0A1Q4PF16
Locus tag OO841_RS06270 Protein ID WP_000813258.1
Coordinates 1298390..1298545 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1298557..1298615 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO841_RS06265 1297926..1298270 - 345 WP_000756595.1 YgiW/YdeI family stress tolerance OB fold protein -
OO841_RS06270 1298390..1298545 - 156 WP_000813258.1 Hok/Gef family protein Toxin
- 1298557..1298615 + 59 - - Antitoxin
OO841_RS06275 1298836..1299231 - 396 WP_000426668.1 hypothetical protein -
OO841_RS06280 1299231..1300129 - 899 Protein_1226 ead/Ea22-like family protein -
OO841_RS06285 1300116..1300400 - 285 WP_001024844.1 DUF4752 family protein -
OO841_RS06290 1300397..1300618 - 222 WP_000763353.1 TraR/DksA family transcriptional regulator -
OO841_RS06295 1300666..1301295 - 630 WP_000203825.1 antA/AntB antirepressor family protein -
OO841_RS06300 1302254..1302361 + 108 WP_001273654.1 KGG domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - stx2A / stx2B 1238746..1303772 65026


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5767.95 Da        Isoelectric Point: 7.7942

>T41915 WP_000813258.1 NZ_AP026087:c1298545-1298390 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Download         Length: 156 bp

>T41915 NZ_AP026087:c1298545-1298390 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 59 bp

>AT41915 NZ_AP026087:1298557-1298615 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4PF16

Antitoxin

Download structure file

References