Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1937477..1937659 Replicon chromosome
Accession NZ_AP024734
Organism Staphylococcus aureus strain 59691

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag OCX19_RS09475 Protein ID WP_001801861.1
Coordinates 1937477..1937572 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1937600..1937659 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX19_RS09435 1933147..1933773 + 627 WP_000669017.1 hypothetical protein -
OCX19_RS09440 1933814..1934155 + 342 WP_000627541.1 DUF3969 family protein -
OCX19_RS09445 1934256..1934828 + 573 WP_000414202.1 hypothetical protein -
OCX19_RS09450 1935026..1935654 - 629 Protein_1861 ImmA/IrrE family metallo-endopeptidase -
OCX19_RS09455 1935769..1935939 - 171 WP_169301139.1 hypothetical protein -
OCX19_RS09460 1935957..1936133 - 177 WP_000375477.1 hypothetical protein -
OCX19_RS09465 1936144..1936527 - 384 Protein_1864 hypothetical protein -
OCX19_RS09470 1937131..1937274 - 144 WP_261921429.1 transposase -
OCX19_RS09475 1937477..1937572 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1937600..1937659 - 60 - - Antitoxin
OCX19_RS09480 1937695..1937796 + 102 WP_001791893.1 hypothetical protein -
OCX19_RS09485 1937774..1937950 - 177 Protein_1868 transposase -
OCX19_RS09490 1938144..1938521 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1931383..1970762 39379


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T39347 WP_001801861.1 NZ_AP024734:1937477-1937572 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T39347 NZ_AP024734:1937477-1937572 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT39347 NZ_AP024734:c1937659-1937600 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References