Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1723191..1723562 Replicon chromosome
Accession NZ_AP018796
Organism Escherichia coli strain E2855

Toxin (Protein)


Gene name ralR Uniprot ID A0A0D6ZRD3
Locus tag MCREHEC_RS08850 Protein ID WP_001443846.1
Coordinates 1723413..1723562 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1723191..1723369 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCREHEC_RS08825 1719146..1720519 + 1374 WP_000123745.1 ATP-dependent RNA helicase DbpA -
MCREHEC_RS08830 1720648..1721583 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
MCREHEC_RS08835 1721635..1722870 - 1236 WP_000040839.1 site-specific integrase -
MCREHEC_RS08840 1722872..1723087 - 216 WP_000079604.1 excisionase XisR -
MCREHEC_RS08845 1723187..1723375 - 189 WP_001302840.1 DUF1187 family protein -
- 1723191..1723369 + 179 NuclAT_0 - Antitoxin
- 1723191..1723369 + 179 NuclAT_0 - Antitoxin
- 1723191..1723369 + 179 NuclAT_0 - Antitoxin
- 1723191..1723369 + 179 NuclAT_0 - Antitoxin
MCREHEC_RS08850 1723413..1723562 - 150 WP_001443846.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
MCREHEC_RS08855 1723618..1724427 - 810 WP_000166313.1 recombination protein RecT -
MCREHEC_RS08860 1724420..1727020 - 2601 WP_000105140.1 exodeoxyribonuclease VIII -
MCREHEC_RS08865 1727122..1727397 - 276 WP_001344816.1 hypothetical protein -
MCREHEC_RS08870 1727472..1727642 - 171 WP_001352098.1 conserved protein, Rac prophage -
MCREHEC_RS08875 1727642..1727863 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1721635..1772094 50459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-48)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5383.12 Da        Isoelectric Point: 8.3398

>T32286 WP_001443846.1 NZ_AP018796:c1723562-1723413 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Download         Length: 150 bp

>T32286 NZ_AP018796:c1723562-1723413 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin


Download         Length: 179 bp

>AT32286 NZ_AP018796:1723191-1723369 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ZRD3

Antitoxin

Download structure file

References