Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1084424..1085925 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag MR177_RS04980 Protein ID WP_003898703.1
Coordinates 1084424..1085305 (-) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag MR177_RS04985 Protein ID WP_003405517.1
Coordinates 1085302..1085925 (-) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS04960 1080145..1080591 - 447 WP_003405595.1 oxidation-sensing regulator MosR -
MR177_RS04965 1080664..1080867 + 204 WP_003405585.1 hypothetical protein -
MR177_RS04970 1080824..1081939 + 1116 WP_003405582.1 hypothetical protein -
MR177_RS04975 1082307..1083554 - 1248 WP_242302868.1 IS256-like element IS1081 family transposase -
MR177_RS04980 1084424..1085305 - 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MR177_RS04985 1085302..1085925 - 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
MR177_RS04990 1086172..1087197 + 1026 WP_003405514.1 serine protease -
MR177_RS04995 1087480..1088407 + 928 Protein_988 IS5-like element ISMt1 family transposase -
MR177_RS05000 1088576..1088815 + 240 WP_003405375.1 hypothetical protein -
MR177_RS05005 1089603..1090430 + 828 WP_003405370.1 PE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1082307..1094061 11754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T295277 WP_003898703.1 NZ_OW052570:c1085305-1084424 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT295277 WP_003405517.1 NZ_OW052570:c1085925-1085302 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References