294488

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1979633..1980245 Replicon chromosome
Accession NZ_NQJO01000001
Organism Erwinia amylovora strain CTBT3-1 tig00000000

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag CS942_RS09305 Protein ID WP_012906750.1
Coordinates 1980066..1980245 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag CS942_RS09300 Protein ID WP_004157632.1
Coordinates 1979633..1980043 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS942_RS09270 1975291..1975881 - 591 WP_223386180.1 DapH/DapD/GlmU-related protein -
CS942_RS09280 1976511..1976783 + 273 WP_004157637.1 hypothetical protein -
CS942_RS19100 1976794..1976967 + 174 WP_013036045.1 hypothetical protein -
CS942_RS19105 1977062..1977235 + 174 WP_004157636.1 hypothetical protein -
CS942_RS09285 1977493..1977705 + 213 WP_004157635.1 hypothetical protein -
CS942_RS09295 1978576..1979577 - 1002 WP_004157633.1 acyltransferase -
CS942_RS09300 1979633..1980043 - 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CS942_RS09305 1980066..1980245 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
CS942_RS09310 1980765..1981493 - 729 WP_099258131.1 two-component system response regulator RstA -
CS942_RS09315 1981670..1982134 + 465 WP_099258132.1 hypothetical protein -
CS942_RS09320 1982138..1983529 - 1392 WP_004157625.1 amino acid permease -
CS942_RS09325 1983737..1984687 - 951 WP_004157624.1 DUF1471 family protein YdgH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1976145..2003667 27522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T294488 WP_012906750.1 NZ_NQJO01000001:c1980245-1980066 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T294488 NZ_NQJO01000001:c1980245-1980066 [Erwinia amylovora]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT294488 WP_004157632.1 NZ_NQJO01000001:c1980043-1979633 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT294488 NZ_NQJO01000001:c1980043-1979633 [Erwinia amylovora]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References