Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 936253..937490 Replicon chromosome
Accession NZ_LS483390
Organism Streptococcus pneumoniae strain NCTC13276

Toxin (Protein)


Gene name pezT Uniprot ID R4H7C0
Locus tag DQM93_RS04980 Protein ID WP_000405357.1
Coordinates 936729..937490 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag DQM93_RS04975 Protein ID WP_000579612.1
Coordinates 936253..936729 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM93_RS04950 931326..932180 + 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -
DQM93_RS04955 932292..933176 + 885 WP_000710119.1 diacylglycerol kinase family lipid kinase -
DQM93_RS04960 933339..935078 + 1740 WP_000423451.1 glycoside hydrolase family 13 protein -
DQM93_RS04965 935164..935481 + 318 WP_000995820.1 hypothetical protein -
DQM93_RS04970 935527..935808 + 282 WP_000266233.1 hypothetical protein -
DQM93_RS04975 936253..936729 + 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
DQM93_RS04980 936729..937490 + 762 WP_000405357.1 zeta toxin family protein Toxin
DQM93_RS04985 937518..938674 + 1157 Protein_923 hypothetical protein -
DQM93_RS04995 939506..939865 + 360 WP_000529543.1 hypothetical protein -
DQM93_RS05000 939875..940204 + 330 WP_000263037.1 MobC family plasmid mobilization relaxosome protein -
DQM93_RS11165 940227..942112 + 1886 Protein_926 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 921609..954370 32761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29044.10 Da        Isoelectric Point: 7.1307

>T292476 WP_000405357.1 NZ_LS483390:936729-937490 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT292476 WP_000579612.1 NZ_LS483390:936253-936729 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R4H7C0

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References