Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1020968..1022205 Replicon chromosome
Accession NZ_LS483374
Organism Streptococcus pneumoniae strain NCTC7466

Toxin (Protein)


Gene name pezT Uniprot ID R4H7C0
Locus tag DQM66_RS05335 Protein ID WP_000405357.1
Coordinates 1020968..1021729 (-) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag DQM66_RS05340 Protein ID WP_000579612.1
Coordinates 1021729..1022205 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM66_RS11190 1016346..1018231 - 1886 Protein_983 relaxase/mobilization nuclease domain-containing protein -
DQM66_RS05315 1018254..1018583 - 330 WP_000263037.1 MobC family plasmid mobilization relaxosome protein -
DQM66_RS05320 1018593..1018952 - 360 WP_000529543.1 hypothetical protein -
DQM66_RS05330 1019784..1020940 - 1157 Protein_986 hypothetical protein -
DQM66_RS05335 1020968..1021729 - 762 WP_000405357.1 zeta toxin family protein Toxin
DQM66_RS05340 1021729..1022205 - 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
DQM66_RS05345 1022650..1022931 - 282 WP_000266233.1 hypothetical protein -
DQM66_RS05350 1022977..1023294 - 318 WP_000995820.1 hypothetical protein -
DQM66_RS05355 1023380..1025119 - 1740 WP_000423451.1 glycoside hydrolase family 13 protein -
DQM66_RS05360 1025282..1026166 - 885 WP_000710119.1 diacylglycerol kinase family lipid kinase -
DQM66_RS05365 1026278..1027132 - 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1002494..1037460 34966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29044.10 Da        Isoelectric Point: 7.1307

>T292449 WP_000405357.1 NZ_LS483374:c1021729-1020968 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT292449 WP_000579612.1 NZ_LS483374:c1022205-1021729 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R4H7C0

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References