Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1835238..1835418 Replicon chromosome
Accession NC_020532
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag SAI3T3_RS15995 Protein ID WP_001801861.1
Coordinates 1835238..1835333 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1835361..1835418 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI3T3_RS08865 1830402..1831052 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
SAI3T3_RS08870 1831133..1832128 + 996 WP_000070642.1 DUF4352 domain-containing protein -
SAI3T3_RS08875 1832203..1832829 + 627 WP_000669024.1 hypothetical protein -
SAI3T3_RS08880 1832870..1833211 + 342 WP_000627540.1 DUF3969 family protein -
SAI3T3_RS08885 1833312..1833884 + 573 WP_000414216.1 hypothetical protein -
SAI3T3_RS15635 1834081..1835093 - 1013 Protein_1702 IS3 family transposase -
SAI3T3_RS15995 1835238..1835333 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1835361..1835418 - 58 - - Antitoxin
SAI3T3_RS14780 1835456..1835557 + 102 WP_001792025.1 hypothetical protein -
SAI3T3_RS16000 1835535..1835696 - 162 Protein_1705 transposase -
SAI3T3_RS08910 1835687..1836181 - 495 Protein_1706 transposase -
SAI3T3_RS08915 1836633..1837859 - 1227 Protein_1707 restriction endonuclease subunit S -
SAI3T3_RS08920 1837852..1839408 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
SAI3T3_RS14785 1839572..1839706 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1830438..1871207 40769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T29062 WP_001801861.1 NC_020532:1835238-1835333 [Staphylococcus aureus subsp. aureus ST228]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T29062 NC_020532:1835238-1835333 [Staphylococcus aureus subsp. aureus ST228]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT29062 NC_020532:c1835418-1835361 [Staphylococcus aureus subsp. aureus ST228]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References