Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1168371..1169872 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag JN986_RS05485 Protein ID WP_003898703.1
Coordinates 1168991..1169872 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID -
Locus tag JN986_RS05480 Protein ID WP_202592751.1
Coordinates 1168371..1168994 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS05460 1163866..1164693 - 828 WP_003405370.1 PE domain-containing protein -
JN986_RS05465 1165481..1165720 - 240 WP_003405375.1 hypothetical protein -
JN986_RS05470 1165889..1166816 - 928 Protein_1077 IS5-like element ISMt1 family transposase -
JN986_RS05475 1167099..1168124 - 1026 WP_003405514.1 serine protease -
JN986_RS05480 1168371..1168994 + 624 WP_202592751.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
JN986_RS05485 1168991..1169872 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN986_RS05490 1170742..1171989 + 1248 WP_202581990.1 IS256 family transposase -
JN986_RS05495 1172357..1173472 - 1116 WP_003405582.1 hypothetical protein -
JN986_RS05500 1173429..1173632 - 204 WP_003405585.1 hypothetical protein -
JN986_RS05505 1173705..1174151 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1160235..1171989 11754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T289859 WP_003898703.1 NZ_LR882499:1168991-1169872 [Mycobacterium tuberculosis variant microti OV254]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22459.62 Da        Isoelectric Point: 10.2679

>AT289859 WP_202592751.1 NZ_LR882499:1168371-1168994 [Mycobacterium tuberculosis variant microti OV254]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAGLRAALDETTAGLRARPKRASA

Download         Length: 624 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N

Antitoxin

Source ID Structure

References