Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1169802..1171303 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag JN980_RS05490 Protein ID WP_003898703.1
Coordinates 1170422..1171303 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag JN980_RS05485 Protein ID WP_003405517.1
Coordinates 1169802..1170425 (+) Length 208 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS05465 1165297..1166124 - 828 WP_003405370.1 PE domain-containing protein -
JN980_RS05470 1166912..1167151 - 240 WP_003405375.1 hypothetical protein -
JN980_RS05475 1167320..1168247 - 928 Protein_1079 IS5-like element ISMt1 family transposase -
JN980_RS05480 1168530..1169555 - 1026 WP_003405514.1 serine protease -
JN980_RS05485 1169802..1170425 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
JN980_RS05490 1170422..1171303 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN980_RS05495 1172173..1173420 + 1248 WP_202581990.1 IS256 family transposase -
JN980_RS05500 1173788..1174903 - 1116 WP_003405582.1 hypothetical protein -
JN980_RS05505 1174860..1175063 - 204 WP_003405585.1 hypothetical protein -
JN980_RS05510 1175136..1175582 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1161666..1173420 11754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T289799 WP_003898703.1 NZ_LR882498:1170422-1171303 [Mycobacterium tuberculosis variant microti]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp


Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT289799 WP_003405517.1 NZ_LR882498:1169802-1170425 [Mycobacterium tuberculosis variant microti]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References