Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | VII | Classification (family/domain) | TglT-TakA/AbiEii-AbiEi |
Location | 1166754..1168255 | Replicon | chromosome |
Accession | NZ_LR699570 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb3601 isolate 14Z005608 |
Toxin (Protein)
Gene name | tglT | Uniprot ID | L7N4P5 |
Locus tag | MBS3601_RS05490 | Protein ID | WP_003898703.1 |
Coordinates | 1167374..1168255 (+) | Length | 294 a.a. |
Antitoxin (Protein)
Gene name | takA | Uniprot ID | L7N5C7 |
Locus tag | MBS3601_RS05485 | Protein ID | WP_003405517.1 |
Coordinates | 1166754..1167377 (+) | Length | 208 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MBS3601_RS05465 | 1162249..1163076 | - | 828 | WP_003405370.1 | PE domain-containing protein | - |
MBS3601_RS05470 | 1163864..1164103 | - | 240 | WP_003405375.1 | hypothetical protein | - |
MBS3601_RS05475 | 1164272..1165199 | - | 928 | Protein_1078 | IS5-like element ISMt1 family transposase | - |
MBS3601_RS05480 | 1165482..1166507 | - | 1026 | WP_011799149.1 | serine protease | - |
MBS3601_RS05485 | 1166754..1167377 | + | 624 | WP_003405517.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
MBS3601_RS05490 | 1167374..1168255 | + | 882 | WP_003898703.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
MBS3601_RS05495 | 1169125..1170372 | + | 1248 | WP_003901078.1 | IS256-like element IS1081 family transposase | - |
MBS3601_RS05500 | 1170740..1171855 | - | 1116 | WP_156068417.1 | hypothetical protein | - |
MBS3601_RS05505 | 1171812..1172015 | - | 204 | WP_003405585.1 | hypothetical protein | - |
MBS3601_RS05510 | 1172088..1172534 | + | 447 | WP_003405595.1 | oxidation-sensing regulator MosR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | IScluster/Tn | - | esxN | 1158618..1170372 | 11754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 294 a.a. Molecular weight: 31958.65 Da Isoelectric Point: 6.3901
>T288826 WP_003898703.1 NZ_LR699570:1167374-1168255 [Mycobacterium tuberculosis variant bovis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
Download Length: 882 bp
Antitoxin
Download Length: 208 a.a. Molecular weight: 22531.68 Da Isoelectric Point: 10.0518
>AT288826 WP_003405517.1 NZ_LR699570:1166754-1167377 [Mycobacterium tuberculosis variant bovis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
Download Length: 624 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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