288210

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 11896..12415 Replicon plasmid 3
Accession NZ_LR135437
Organism Enterococcus faecium isolate E8691

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag EQB50_RS14390 Protein ID WP_000588503.1
Coordinates 12158..12415 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag EQB50_RS14385 Protein ID WP_000388479.1
Coordinates 11896..12165 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB50_RS14340 7003..7911 + 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
EQB50_RS14345 7908..8450 + 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
EQB50_RS14350 8543..9337 + 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
EQB50_RS14360 9613..9726 + 114 Protein_13 HTH domain-containing protein -
EQB50_RS14365 9768..10448 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EQB50_RS14370 10510..11205 + 696 WP_002326819.1 hypothetical protein -
EQB50_RS14380 11586..11765 + 180 WP_001120991.1 hypothetical protein -
EQB50_RS14385 11896..12165 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB50_RS14390 12158..12415 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
EQB50_RS14395 12874..13878 + 1005 WP_000455809.1 hypothetical protein -
EQB50_RS14400 14043..14657 - 615 WP_001261742.1 recombinase family protein -
EQB50_RS14405 15107..16432 + 1326 WP_000969590.1 Y-family DNA polymerase -
EQB50_RS14410 16425..16775 + 351 WP_000568378.1 hypothetical protein -
EQB50_RS14415 16772..16951 + 180 WP_001021554.1 hypothetical protein -
EQB50_RS14420 17087..17377 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III - 1..19194 19194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T288210 WP_000588503.1 NZ_LR135437:12158-12415 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT288210 WP_000388479.1 NZ_LR135437:11896-12165 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References