Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1947264..1947446 Replicon chromosome
Accession NZ_LR130518
Organism Staphylococcus aureus strain BPH2986 isolate BPH2986

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag EW031_RS10030 Protein ID WP_001801861.1
Coordinates 1947264..1947359 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1947387..1947446 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW031_RS09980 1942924..1943550 + 627 Protein_1880 hypothetical protein -
EW031_RS09985 1943591..1943935 + 345 WP_000627551.1 DUF3969 family protein -
EW031_RS09990 1944033..1944584 + 552 WP_000414205.1 hypothetical protein -
EW031_RS09995 1944802..1945443 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
EW031_RS10000 1945557..1945742 - 186 WP_000809857.1 hypothetical protein -
EW031_RS10005 1945744..1945920 - 177 WP_000375476.1 hypothetical protein -
EW031_RS10010 1945931..1946314 - 384 WP_000070811.1 hypothetical protein -
EW031_RS10020 1946918..1947061 - 144 WP_001549059.1 transposase -
EW031_RS10030 1947264..1947359 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1947387..1947446 - 60 - - Antitoxin
EW031_RS10035 1947482..1947583 + 102 WP_001791893.1 hypothetical protein -
EW031_RS10040 1947561..1947737 - 177 Protein_1890 transposase -
EW031_RS10045 1947931..1948308 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1940364..1980536 40172
- inside Prophage - lukD / hlgA 1909824..2028198 118374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T286180 WP_001801861.1 NZ_LR130518:1947264-1947359 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T286180 NZ_LR130518:1947264-1947359 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT286180 NZ_LR130518:c1947446-1947387 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References