285643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1624659..1625896 Replicon chromosome
Accession NZ_LN831051
Organism Streptococcus pneumoniae strain NCTC7465

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag AT689_RS08580 Protein ID WP_000405367.1
Coordinates 1624659..1625420 (-) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag AT689_RS08585 Protein ID WP_000579612.1
Coordinates 1625420..1625896 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT689_RS11975 1620070..1621935 - 1866 Protein_1610 relaxase/mobilization nuclease domain-containing protein -
AT689_RS08565 1621922..1622220 - 299 Protein_1611 MobC family plasmid mobilization relaxosome protein -
AT689_RS08570 1622296..1622655 - 360 WP_000003746.1 hypothetical protein -
AT689_RS08575 1623474..1624631 - 1158 WP_001213953.1 hypothetical protein -
AT689_RS08580 1624659..1625420 - 762 WP_000405367.1 zeta toxin family protein Toxin
AT689_RS08585 1625420..1625896 - 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
AT689_RS08590 1626341..1626796 - 456 WP_000500470.1 hypothetical protein -
AT689_RS08600 1627071..1628808 - 1738 Protein_1617 alpha-glycosidase -
AT689_RS08605 1628971..1629855 - 885 WP_000710109.1 diacylglycerol kinase family lipid kinase -
AT689_RS08610 1629967..1630821 - 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1610627..1641675 31048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29123.21 Da        Isoelectric Point: 8.6519

>T285643 WP_000405367.1 NZ_LN831051:c1625420-1624659 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLHELLFGEWSQVEKEML
RVGEKRLNELLEK

Download         Length: 762 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT285643 WP_000579612.1 NZ_LN831051:c1625896-1625420 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References