285555

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2884231..2884813 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name PumA Uniprot ID D3VJ77
Locus tag XNC2_RS12065 Protein ID WP_013184681.1
Coordinates 2884231..2884518 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag XNC2_RS12070 Protein ID WP_010846808.1
Coordinates 2884529..2884813 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS23485 2880867..2881091 + 225 WP_010846802.1 hypothetical protein -
XNC2_RS20875 2881215..2882086 + 872 Protein_2387 IS630 family transposase -
XNC2_RS12045 2882416..2882841 - 426 WP_012987825.1 type II toxin-antitoxin system VapC family toxin -
XNC2_RS12050 2882841..2883095 - 255 WP_010846804.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
XNC2_RS12055 2883320..2883649 + 330 WP_010846805.1 type I toxin-antitoxin system SymE family toxin -
XNC2_RS12060 2883790..2884128 + 339 WP_010846806.1 SymE family type I addiction module toxin -
XNC2_RS12065 2884231..2884518 + 288 WP_013184681.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XNC2_RS12070 2884529..2884813 + 285 WP_010846808.1 putative addiction module antidote protein Antitoxin
XNC2_RS12075 2884896..2885279 - 384 WP_013184682.1 hypothetical protein -
XNC2_RS12080 2885400..2885609 - 210 WP_013184683.1 hypothetical protein -
XNC2_RS12085 2885820..2886134 - 315 WP_013184684.1 hypothetical protein -
XNC2_RS12090 2886138..2886662 - 525 WP_013184685.1 hypothetical protein -
XNC2_RS23490 2886666..2886776 - 111 Protein_2398 RHS repeat protein -
XNC2_RS12105 2887274..2887465 - 192 WP_143767649.1 hypothetical protein -
XNC2_RS12110 2887495..2888496 - 1002 WP_013184689.1 site-specific tyrosine recombinase XerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2878955..2939670 60715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10773.43 Da        Isoelectric Point: 10.0371

>T285555 WP_013184681.1 NZ_LN681227:2884231-2884518 [Xenorhabdus nematophila AN6/1]
MITIERTQNFEKWLKSLKDRIAKAKILIRVERMGEGNFGDVESVGGGVSELRIHYGQGYRVYFTNKNNEIILLLCGGDKS
SQQADIKKAKQLAKE

Download         Length: 288 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10443.90 Da        Isoelectric Point: 9.3655

>AT285555 WP_010846808.1 NZ_LN681227:2884529-2884813 [Xenorhabdus nematophila AN6/1]
MKSAPKKFDVVEFLETEEDIQAYLNAAIEENDTKYLFKALGNIARRKNISQLSKESGISREGIYKALSGEGNPSFNTVYK
ISKALGLKLHFTGA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VJ77

Antitoxin

Source ID Structure

References