Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 2884536..2885118 | Replicon | chromosome |
| Accession | NC_014228 | ||
| Organism | Xenorhabdus nematophila ATCC 19061 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | D3VJ77 |
| Locus tag | XNC1_RS12050 | Protein ID | WP_013184681.1 |
| Coordinates | 2884536..2884823 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | XNC1_RS12055 | Protein ID | WP_010846808.1 |
| Coordinates | 2884834..2885118 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XNC1_RS23815 (XNC1_2873) | 2881172..2881396 | + | 225 | WP_010846802.1 | hypothetical protein | - |
| XNC1_RS21515 | 2881520..2882391 | + | 872 | Protein_2387 | IS630 family transposase | - |
| XNC1_RS12030 (XNC1_2876) | 2882721..2883146 | - | 426 | WP_012987825.1 | type II toxin-antitoxin system VapC family toxin | - |
| XNC1_RS12035 (XNC1_2877) | 2883146..2883400 | - | 255 | WP_010846804.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| XNC1_RS12040 (XNC1_2878) | 2883625..2883954 | + | 330 | WP_010846805.1 | type I toxin-antitoxin system SymE family toxin | - |
| XNC1_RS12045 (XNC1_2879) | 2884095..2884433 | + | 339 | WP_010846806.1 | SymE family type I addiction module toxin | - |
| XNC1_RS12050 (XNC1_2880) | 2884536..2884823 | + | 288 | WP_013184681.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| XNC1_RS12055 (XNC1_2881) | 2884834..2885118 | + | 285 | WP_010846808.1 | putative addiction module antidote protein | Antitoxin |
| XNC1_RS12060 (XNC1_2882) | 2885201..2885584 | - | 384 | WP_013184682.1 | hypothetical protein | - |
| XNC1_RS12065 (XNC1_2883) | 2885705..2885914 | - | 210 | WP_013184683.1 | hypothetical protein | - |
| XNC1_RS12070 (XNC1_2884) | 2886125..2886439 | - | 315 | WP_013184684.1 | hypothetical protein | - |
| XNC1_RS12075 (XNC1_2885) | 2886443..2886967 | - | 525 | WP_013184685.1 | hypothetical protein | - |
| XNC1_RS23750 | 2886971..2887081 | - | 111 | Protein_2398 | RHS repeat protein | - |
| XNC1_RS12090 (XNC1_2887) | 2887579..2887770 | - | 192 | WP_143767649.1 | hypothetical protein | - |
| XNC1_RS12095 (XNC1_2889) | 2887800..2888801 | - | 1002 | WP_013184689.1 | site-specific tyrosine recombinase XerC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Integrative and Conjugative Element | - | - | 2879260..2940004 | 60744 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10773.43 Da Isoelectric Point: 10.0371
>T24800 WP_013184681.1 NC_014228:2884536-2884823 [Xenorhabdus nematophila ATCC 19061]
MITIERTQNFEKWLKSLKDRIAKAKILIRVERMGEGNFGDVESVGGGVSELRIHYGQGYRVYFTNKNNEIILLLCGGDKS
SQQADIKKAKQLAKE
MITIERTQNFEKWLKSLKDRIAKAKILIRVERMGEGNFGDVESVGGGVSELRIHYGQGYRVYFTNKNNEIILLLCGGDKS
SQQADIKKAKQLAKE
Download Length: 288 bp
>T24800 NC_014228:2884536-2884823 [Xenorhabdus nematophila ATCC 19061]
ATGATAACCATTGAAAGGACACAAAATTTTGAAAAATGGTTAAAATCCTTAAAAGACCGAATAGCAAAAGCCAAAATCTT
AATCAGAGTTGAAAGAATGGGAGAGGGCAATTTTGGTGATGTTGAATCGGTGGGAGGTGGAGTTTCGGAACTCAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTACTAACAAAAATAATGAAATCATATTATTACTCTGTGGCGGGGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCCAAACAACTCGCGAAAGAATGA
ATGATAACCATTGAAAGGACACAAAATTTTGAAAAATGGTTAAAATCCTTAAAAGACCGAATAGCAAAAGCCAAAATCTT
AATCAGAGTTGAAAGAATGGGAGAGGGCAATTTTGGTGATGTTGAATCGGTGGGAGGTGGAGTTTCGGAACTCAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTACTAACAAAAATAATGAAATCATATTATTACTCTGTGGCGGGGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCCAAACAACTCGCGAAAGAATGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10443.90 Da Isoelectric Point: 9.3655
>AT24800 WP_010846808.1 NC_014228:2884834-2885118 [Xenorhabdus nematophila ATCC 19061]
MKSAPKKFDVVEFLETEEDIQAYLNAAIEENDTKYLFKALGNIARRKNISQLSKESGISREGIYKALSGEGNPSFNTVYK
ISKALGLKLHFTGA
MKSAPKKFDVVEFLETEEDIQAYLNAAIEENDTKYLFKALGNIARRKNISQLSKESGISREGIYKALSGEGNPSFNTVYK
ISKALGLKLHFTGA
Download Length: 285 bp
>AT24800 NC_014228:2884834-2885118 [Xenorhabdus nematophila ATCC 19061]
ATGAAATCAGCACCAAAAAAATTTGATGTTGTGGAGTTTTTAGAAACAGAAGAAGATATTCAGGCATACTTAAATGCCGC
TATCGAAGAAAACGATACAAAATATTTATTTAAAGCATTAGGTAATATCGCCAGAAGAAAAAATATCAGCCAACTCTCGA
AAGAATCAGGAATAAGCCGAGAAGGGATATATAAGGCGTTATCCGGTGAAGGCAATCCATCGTTTAATACGGTATACAAA
ATATCGAAAGCACTGGGTTTGAAACTGCATTTTACGGGGGCTTAA
ATGAAATCAGCACCAAAAAAATTTGATGTTGTGGAGTTTTTAGAAACAGAAGAAGATATTCAGGCATACTTAAATGCCGC
TATCGAAGAAAACGATACAAAATATTTATTTAAAGCATTAGGTAATATCGCCAGAAGAAAAAATATCAGCCAACTCTCGA
AAGAATCAGGAATAAGCCGAGAAGGGATATATAAGGCGTTATCCGGTGAAGGCAATCCATCGTTTAATACGGTATACAAA
ATATCGAAAGCACTGGGTTTGAAACTGCATTTTACGGGGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|