Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2320543..2321174 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag XNC2_RS10020 Protein ID WP_113967504.1
Coordinates 2320543..2320821 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D3VGL4
Locus tag XNC2_RS10025 Protein ID WP_013184418.1
Coordinates 2320818..2321174 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS10000 2316532..2317149 + 618 WP_013184413.1 hypothetical protein -
XNC2_RS10005 2317131..2317364 + 234 WP_013184414.1 hypothetical protein -
XNC2_RS10010 2317364..2319550 + 2187 WP_013184415.1 DNA topoisomerase 3 -
XNC2_RS10015 2319608..2319907 + 300 Protein_1984 transposase -
XNC2_RS10020 2320543..2320821 + 279 WP_113967504.1 type II toxin-antitoxin system HicA family toxin Toxin
XNC2_RS10025 2320818..2321174 + 357 WP_013184418.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
XNC2_RS10030 2321620..2322330 - 711 WP_013184420.1 portal protein -
XNC2_RS10035 2322336..2322728 - 393 Protein_1988 transposase -
XNC2_RS10040 2322887..2323633 + 747 Protein_1989 IS630 family transposase -
XNC2_RS10045 2323635..2324684 + 1050 Protein_1990 Tn3 family transposase -
XNC2_RS10050 2324769..2325791 + 1023 WP_010845954.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2312102..2348646 36544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(59-111)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10130.58 Da        Isoelectric Point: 10.6521

>T285554 WP_113967504.1 NZ_LN681227:2320543-2320821 [Xenorhabdus nematophila AN6/1]
MNKQVSALRTRQQRTLEQIFKTPVSSGIKWSDIESLIKALGGEIKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVAGL
REWLESIGVTPS

Download         Length: 279 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13289.10 Da        Isoelectric Point: 5.6614

>AT285554 WP_013184418.1 NZ_LN681227:2320818-2321174 [Xenorhabdus nematophila AN6/1]
MSKQNTNIMEIAGLSAVISYVPELGMFRGKFLGLSGYCDFVADSIAGLHAEGRLSLDEYLEDCRAANIEPYQKREKTKTF
TLRYPESFGERLNQAATEHHISVNAFILETLGERLRNI

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB D3VGL4

References