Detailed information of TA system TA024799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2320808..2321439
• Replicon: chromosome
• Accession: NC_014228
• Organism: Xenorhabdus nematophila ATCC 19061

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: XNC1_RS10010
• Protein ID: WP_113967504.1
• Coordinates: 2320808..2321086 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: D3VGL4
• Locus tag: XNC1_RS10015
• Protein ID: WP_013184418.1
• Coordinates: 2321083..2321439 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XNC1_RS09990 (XNC1_2385)	2316797..2317414	+	618	WP_013184413.1	hypothetical protein	-
XNC1_RS09995 (XNC1_2386)	2317396..2317629	+	234	WP_013184414.1	hypothetical protein	-
XNC1_RS10000 (XNC1_2387)	2317629..2319815	+	2187	WP_013184415.1	DNA topoisomerase 3	-
XNC1_RS10005 (XNC1_2389)	2319873..2320172	+	300	Protein_1985	transposase	-
XNC1_RS10010 (XNC1_2390)	2320808..2321086	+	279	WP_113967504.1	type II toxin-antitoxin system HicA family toxin	Toxin
XNC1_RS10015 (XNC1_2391)	2321083..2321439	+	357	WP_013184418.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
XNC1_RS10020 (XNC1_2393)	2321885..2322595	-	711	WP_013184420.1	portal protein	-
XNC1_RS10025	2322601..2322993	-	393	Protein_1989	transposase	-
XNC1_RS10030 (XNC1_2395)	2323152..2323898	+	747	Protein_1990	IS630 family transposase	-
XNC1_RS10035 (XNC1_2396)	2323900..2324949	+	1050	Protein_1991	Tn3 family transposase	-
XNC1_RS10040 (XNC1_2397)	2325034..2326056	+	1023	WP_010845954.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_LN681227 Xenorhabdus nematophila AN6/1 Integrative and Conjugative Element TA285554 2312102..2348646 0	inside	Integrative and Conjugative Element	-	-	2312367..2348951	36584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (59-111)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10130.58 Da
• Isoelectric Point: 10.6521

>T24799 WP_113967504.1 NC_014228:2320808-2321086 [Xenorhabdus nematophila ATCC 19061]
MNKQVSALRTRQQRTLEQIFKTPVSSGIKWSDIESLIKALGGEIKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVAGL
REWLESIGVTPS

Nucleotide

• Length: 279 bp

>T24799 NC_014228:2320808-2321086 [Xenorhabdus nematophila ATCC 19061]
ATGAACAAACAGGTTTCAGCGCTCCGAACGAGGCAACAACGTACCTTAGAACAAATTTTTAAAACGCCGGTATCGTCGGG
AATTAAATGGTCAGATATTGAATCGTTAATCAAGGCATTGGGCGGTGAAATCAAGGAAGGCCGAGGTTCGCGTTGTAAAT
TTTTACTGAATGGGAGTATTGCCAATTTTCATCGCCCCCATCCGTCACCCGACACAGACAAAGGGGCTGTGGCGGGATTA
CGGGAATGGTTGGAAAGTATAGGAGTCACACCATCATGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13289.10 Da
• Isoelectric Point: 5.6614

>AT24799 WP_013184418.1 NC_014228:2321083-2321439 [Xenorhabdus nematophila ATCC 19061]
MSKQNTNIMEIAGLSAVISYVPELGMFRGKFLGLSGYCDFVADSIAGLHAEGRLSLDEYLEDCRAANIEPYQKREKTKTF
TLRYPESFGERLNQAATEHHISVNAFILETLGERLRNI

Nucleotide

• Length: 357 bp

>AT24799 NC_014228:2321083-2321439 [Xenorhabdus nematophila ATCC 19061]
ATGAGTAAGCAAAATACCAATATTATGGAGATCGCCGGACTCTCGGCGGTGATTAGTTATGTCCCTGAACTCGGTATGTT
TCGGGGGAAGTTTTTAGGGTTATCCGGTTATTGTGATTTTGTGGCTGACAGTATTGCTGGGCTGCATGCTGAAGGGCGAT
TGTCTTTAGATGAATATTTAGAAGACTGCCGAGCCGCCAATATCGAGCCTTATCAGAAACGTGAAAAAACAAAAACGTTT
ACTTTACGTTACCCCGAATCGTTTGGCGAACGGTTAAATCAGGCTGCAACCGAACACCATATTTCGGTCAACGCGTTCAT
TTTGGAGACATTGGGTGAGCGCCTGAGAAACATCTAA

Structures

Antitoxin

• AlphaFold DB: D3VGL4