285547

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 179959..180575 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name doc Uniprot ID D3VH06
Locus tag XNC2_RS00880 Protein ID WP_013183155.1
Coordinates 180177..180575 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID N1NKK1
Locus tag XNC2_RS00875 Protein ID WP_010847654.1
Coordinates 179959..180180 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS20970 175854..176066 + 213 WP_013183151.1 ogr/Delta-like zinc finger family protein -
XNC2_RS00860 176776..177591 + 816 WP_010847649.1 DNA damage-inducible protein D -
XNC2_RS00865 177930..178490 + 561 Protein_171 DUF4102 domain-containing protein -
XNC2_RS00870 178698..179738 - 1041 WP_013141539.1 IS481 family transposase -
XNC2_RS00875 179959..180180 + 222 WP_010847654.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
XNC2_RS00880 180177..180575 + 399 WP_013183155.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
XNC2_RS00885 180817..181716 - 900 Protein_175 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
XNC2_RS00890 181779..182555 - 777 WP_010847657.1 type IV toxin-antitoxin system AbiEi family antitoxin -
XNC2_RS00895 183071..183838 - 768 WP_013183157.1 triose-phosphate isomerase -
XNC2_RS00900 183927..184547 - 621 WP_013183158.1 DUF1454 family protein -
XNC2_RS00905 184606..185052 + 447 WP_041573628.1 DUF805 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 163360..180575 17215
flank IS/Tn - - 178698..179738 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14931.84 Da        Isoelectric Point: 6.3262

>T285547 WP_013183155.1 NZ_LN681227:180177-180575 [Xenorhabdus nematophila AN6/1]
MIWVSAQEVIAFHDRILQRLPGVAGMPDSGRAEALIYRVQNRTHHEGITDIFELAATYWAAIARGHIFNDGNKRTAFFVT
MTFLYRNGIKIRDNDNTLENLTVDAATGEKTVDQLAQHLRELVDYTNPSCNP

Download         Length: 399 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8171.99 Da        Isoelectric Point: 5.5589

>AT285547 WP_010847654.1 NZ_LN681227:179959-180180 [Xenorhabdus nematophila AN6/1]
MRTYTSTQARANIAEVLDTAAHGEPVEITRRDGSSAVVISRAEFDNWQNAKLDAEFDSIMQRHGHTIEALTNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VH06

Antitoxin

Source ID Structure
AlphaFold DB N1NKK1

References