24792

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 179958..180574 Replicon chromosome
Accession NC_014228
Organism Xenorhabdus nematophila ATCC 19061

Toxin (Protein)


Gene name doc Uniprot ID D3VH06
Locus tag XNC1_RS00885 Protein ID WP_013183155.1
Coordinates 180176..180574 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID N1NKK1
Locus tag XNC1_RS00880 Protein ID WP_010847654.1
Coordinates 179958..180179 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC1_RS20870 (XNC1_0192) 175853..176065 + 213 WP_013183151.1 ogr/Delta-like zinc finger family protein -
XNC1_RS00865 (XNC1_0195) 176775..177590 + 816 WP_010847649.1 DNA damage-inducible protein D -
XNC1_RS00870 177929..178489 + 561 Protein_171 DUF4102 domain-containing protein -
XNC1_RS00875 (XNC1_0201) 178697..179737 - 1041 WP_013141539.1 IS481 family transposase -
XNC1_RS00880 (XNC1_0202) 179958..180179 + 222 WP_010847654.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
XNC1_RS00885 (XNC1_0203) 180176..180574 + 399 WP_013183155.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
XNC1_RS00890 180816..181715 - 900 Protein_175 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
XNC1_RS00895 (XNC1_0206) 181778..182554 - 777 WP_010847657.1 type IV toxin-antitoxin system AbiEi family antitoxin -
XNC1_RS00900 (XNC1_0208) 183070..183837 - 768 WP_013183157.1 triose-phosphate isomerase -
XNC1_RS00905 (XNC1_0209) 183926..184546 - 621 WP_013183158.1 DUF1454 family protein -
XNC1_RS00910 (XNC1_0210) 184605..185051 + 447 WP_041573628.1 DUF805 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 163359..180574 17215
flank IS/Tn - - 178697..179737 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14931.84 Da        Isoelectric Point: 6.3262

>T24792 WP_013183155.1 NC_014228:180176-180574 [Xenorhabdus nematophila ATCC 19061]
MIWVSAQEVIAFHDRILQRLPGVAGMPDSGRAEALIYRVQNRTHHEGITDIFELAATYWAAIARGHIFNDGNKRTAFFVT
MTFLYRNGIKIRDNDNTLENLTVDAATGEKTVDQLAQHLRELVDYTNPSCNP

Download         Length: 399 bp

>T24792 NC_014228:180176-180574 [Xenorhabdus nematophila ATCC 19061]
ATGATATGGGTCAGCGCACAGGAAGTTATCGCTTTTCATGACCGAATATTACAACGGCTTCCCGGCGTTGCCGGAATGCC
CGATTCTGGTAGAGCTGAAGCGCTCATCTATCGGGTACAAAACCGTACACACCATGAAGGCATAACAGATATTTTTGAAC
TTGCAGCTACCTATTGGGCTGCTATCGCTCGTGGTCATATTTTCAATGATGGTAATAAGCGCACAGCGTTTTTCGTTACC
ATGACTTTTCTCTATCGTAACGGTATCAAGATCCGTGATAACGACAATACATTGGAAAACTTAACAGTAGATGCCGCTAC
GGGCGAGAAAACCGTTGACCAGTTGGCGCAGCACCTGCGCGAATTGGTGGACTATACTAACCCGAGCTGTAATCCATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8171.99 Da        Isoelectric Point: 5.5589

>AT24792 WP_010847654.1 NC_014228:179958-180179 [Xenorhabdus nematophila ATCC 19061]
MRTYTSTQARANIAEVLDTAAHGEPVEITRRDGSSAVVISRAEFDNWQNAKLDAEFDSIMQRHGHTIEALTNR

Download         Length: 222 bp

>AT24792 NC_014228:179958-180179 [Xenorhabdus nematophila ATCC 19061]
ATGCGTACATACACCTCAACTCAAGCCCGTGCCAACATCGCGGAAGTGTTGGACACAGCGGCTCACGGTGAACCTGTTGA
AATCACTCGTCGAGACGGTAGTTCAGCGGTCGTTATCAGTAGAGCTGAATTCGATAATTGGCAAAACGCTAAGCTGGATG
CAGAGTTCGATTCGATTATGCAACGTCATGGGCATACGATAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VH06

Antitoxin

Source ID Structure
AlphaFold DB N1NKK1

References