Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 3337427..3337642 Replicon chromosome
Accession NZ_LN614756
Organism Clostridioides difficile strain 630Derm

Toxin (Protein)


Gene name CD2889 Uniprot ID Q183X5
Locus tag CD630DERM_RS21030 Protein ID WP_011861731.1
Coordinates 3337499..3337642 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 3337427..3337573 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD630DERM_RS15480 3333086..3334240 + 1155 WP_003439713.1 GGDEF domain-containing protein -
CD630DERM_RS15485 3334321..3336039 - 1719 WP_011861730.1 putative 2-aminoethylphosphonate ABC transporter permease subunit -
CD630DERM_RS15490 3336044..3336925 - 882 Protein_2954 ATP-binding cassette domain-containing protein -
- 3337427..3337573 + 147 NuclAT_2 - Antitoxin
- 3337427..3337577 + 151 NuclAT_1 - -
CD630DERM_RS21030 3337499..3337642 - 144 WP_011861731.1 hypothetical protein Toxin
CD630DERM_RS15500 3337900..3338088 + 189 WP_009898401.1 hypothetical protein -
CD630DERM_RS15505 3338335..3339039 - 705 WP_011861732.1 hypothetical protein -
CD630DERM_RS15510 3339041..3339472 - 432 WP_011861052.1 protein-export chaperone SecB -
CD630DERM_RS15515 3339490..3340053 - 564 WP_021371073.1 hypothetical protein -
CD630DERM_RS15520 3340599..3340895 - 297 WP_011861049.1 hypothetical protein -
CD630DERM_RS15525 3340912..3341727 - 816 WP_011861048.1 N-acetylmuramoyl-L-alanine amidase -
CD630DERM_RS15530 3341724..3341984 - 261 WP_011861047.1 phage holin family protein -
CD630DERM_RS15535 3342004..3342234 - 231 WP_011861046.1 hemolysin XhlA family protein -
CD630DERM_RS15540 3342269..3342451 - 183 WP_011861045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5399.34 Da        Isoelectric Point: 10.8277

>T285475 WP_011861731.1 NZ_LN614756:c3337642-3337499 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH

Download         Length: 144 bp

Antitoxin


Download         Length: 147 bp

>AT285475 NZ_LN614756:3337427-3337573 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A3R1

Antitoxin

Download structure file

References