Detailed information of TA system TA285475

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3337427..3337642
• Replicon: chromosome
• Accession: NZ_LN614756
• Organism: Clostridioides difficile strain 630Derm

Toxin (Protein)

• Gene name: CD2889
• Uniprot ID: Q183X5
• Locus tag: CD630DERM_RS21030
• Protein ID: WP_011861731.1
• Coordinates: 3337499..3337642 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	3337427..3337573 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD630DERM_RS15480	3333086..3334240	+	1155	WP_003439713.1	GGDEF domain-containing protein	-
CD630DERM_RS15485	3334321..3336039	-	1719	WP_011861730.1	putative 2-aminoethylphosphonate ABC transporter permease subunit	-
CD630DERM_RS15490	3336044..3336925	-	882	Protein_2954	ATP-binding cassette domain-containing protein	-
-	3337427..3337573	+	147	NuclAT_2	-	Antitoxin
-	3337427..3337577	+	151	NuclAT_1	-	-
CD630DERM_RS21030	3337499..3337642	-	144	WP_011861731.1	hypothetical protein	Toxin
CD630DERM_RS15500	3337900..3338088	+	189	WP_009898401.1	hypothetical protein	-
CD630DERM_RS15505	3338335..3339039	-	705	WP_011861732.1	hypothetical protein	-
CD630DERM_RS15510	3339041..3339472	-	432	WP_011861052.1	protein-export chaperone SecB	-
CD630DERM_RS15515	3339490..3340053	-	564	WP_021371073.1	hypothetical protein	-
CD630DERM_RS15520	3340599..3340895	-	297	WP_011861049.1	hypothetical protein	-
CD630DERM_RS15525	3340912..3341727	-	816	WP_011861048.1	N-acetylmuramoyl-L-alanine amidase	-
CD630DERM_RS15530	3341724..3341984	-	261	WP_011861047.1	phage holin family protein	-
CD630DERM_RS15535	3342004..3342234	-	231	WP_011861046.1	hemolysin XhlA family protein	-
CD630DERM_RS15540	3342269..3342451	-	183	WP_011861045.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5399.34 Da
• Isoelectric Point: 10.8277

>T285475 WP_011861731.1 NZ_LN614756:c3337642-3337499 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 147 bp

>AT285475 NZ_LN614756:3337427-3337573 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT

Structures

Toxin

• AlphaFold DB: A0A069A3R1

Antitoxin