Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2865442..2865651 Replicon chromosome
Accession NZ_LN614756
Organism Clostridioides difficile strain 630Derm

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CD630DERM_RS21015 Protein ID WP_004454815.1
Coordinates 2865493..2865651 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2865442..2865576 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD630DERM_RS13560 2861012..2862640 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CD630DERM_RS13565 2862761..2863756 + 996 WP_003431031.1 asparaginase -
CD630DERM_RS13570 2863934..2864317 - 384 WP_011861577.1 BlaI/MecI/CopY family transcriptional regulator -
- 2865442..2865576 + 135 NuclAT_4 - Antitoxin
CD630DERM_RS21015 2865493..2865651 - 159 WP_004454815.1 hypothetical protein Toxin
CD630DERM_RS13580 2866010..2867380 - 1371 WP_011861578.1 cell wall-binding protein Cwp29 -
CD630DERM_RS13585 2867594..2868712 + 1119 WP_011861579.1 site-specific integrase -
CD630DERM_RS13590 2869029..2869697 - 669 WP_011861580.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T285473 WP_004454815.1 NZ_LN614756:c2865651-2865493 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

Antitoxin


Download         Length: 135 bp

>AT285473 NZ_LN614756:2865442-2865576 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References