283053

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2432232..2433820 Replicon chromosome
Accession NZ_CP126928
Organism Escherichia coli O2:K1:H4 strain APEC E12053

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag QQA27_RS11810 Protein ID WP_001125475.1
Coordinates 2432232..2433554 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA27_RS11815 Protein ID WP_001332145.1
Coordinates 2433554..2433820 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA27_RS11785 (2428710) 2428710..2429420 - 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -
QQA27_RS11790 (2429485) 2429485..2430048 - 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
QQA27_RS11795 (2430473) 2430473..2430568 + 96 Protein_2308 hypothetical protein -
QQA27_RS11800 (2430824) 2430824..2431606 - 783 WP_001221834.1 SDR family oxidoreductase -
QQA27_RS11805 (2431740) 2431740..2431922 + 183 Protein_2310 hypothetical protein -
QQA27_RS11810 (2432232) 2432232..2433554 - 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA27_RS11815 (2433554) 2433554..2433820 - 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA27_RS11820 (2434128) 2434128..2434886 + 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
QQA27_RS11825 (2434890) 2434890..2435804 - 915 WP_001306069.1 bestrophin family protein -
QQA27_RS11830 (2436001) 2436001..2437452 - 1452 WP_001513806.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimA 2416791..2433820 17029


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T283053 WP_001125475.1 NZ_CP126928:c2433554-2432232 [Escherichia coli O2:K1:H4]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT283053 WP_001332145.1 NZ_CP126928:c2433820-2433554 [Escherichia coli O2:K1:H4]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References