Detailed information of TA system TA282777

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3659301..3659733
• Replicon: chromosome
• Accession: NZ_CP126325
• Organism: Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V6CTL5
• Locus tag: QN088_RS17895
• Protein ID: WP_000994227.1
• Coordinates: 3659458..3659733 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3659301..3659723 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QN088_RS17865	3654559..3655053	-	495	WP_023228257.1	Saf-pilin pilus formation protein SafA	-
QN088_RS17870	3655821..3656522	-	702	Protein_3494	integrase core domain-containing protein	-
QN088_RS17875	3656575..3656805	+	231	Protein_3495	SymE family type I addiction module toxin	-
QN088_RS17880	3656956..3657234	-	279	WP_077911363.1	hypothetical protein	-
QN088_RS17885	3657551..3658018	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
QN088_RS17890	3658891..3659124	-	234	WP_124084119.1	hypothetical protein	-
-	3659301..3659723	-	423	-	-	Antitoxin
QN088_RS17895	3659458..3659733	+	276	WP_000994227.1	SymE family type I addiction module toxin	Toxin
QN088_RS17900	3659781..3660212	-	432	WP_000778566.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3646037..3682406	36369
	-	flank	IS/Tn	-	-	3655821..3656099	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10090.38 Da
• Isoelectric Point: 6.8602

>T282777 WP_000994227.1 NZ_CP126325:3659458-3659733 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEDAGFETGRSVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT282777 NZ_CP126325:c3659723-3659301 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAAATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCGT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V6CTL5

Antitoxin