Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1731652..1731872 Replicon chromosome
Accession NZ_CP126076
Organism Clostridioides difficile strain CDI-01

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag ITJ31_RS08170 Protein ID WP_003429855.1
Coordinates 1731652..1731813 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1731733..1731872 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITJ31_RS08140 (ITJ31_008140) 1727509..1727946 + 438 WP_009888839.1 hypothetical protein -
ITJ31_RS08145 (ITJ31_008145) 1727939..1728115 + 177 WP_009888840.1 hypothetical protein -
ITJ31_RS08150 (ITJ31_008150) 1728116..1729426 + 1311 WP_009893136.1 phage tail sheath family protein -
ITJ31_RS08155 (ITJ31_008155) 1729443..1729913 + 471 WP_009888842.1 phage tail tube protein -
ITJ31_RS08160 (ITJ31_008160) 1729972..1730799 + 828 WP_009888843.1 hypothetical protein -
ITJ31_RS08165 (ITJ31_008165) 1730871..1731311 + 441 WP_003429853.1 phage portal protein -
ITJ31_RS08170 (ITJ31_008170) 1731652..1731813 + 162 WP_003429855.1 hypothetical protein Toxin
- 1731733..1731872 - 140 - - Antitoxin
ITJ31_RS08175 (ITJ31_008175) 1733150..1733338 + 189 WP_003429858.1 hypothetical protein -
ITJ31_RS08180 (ITJ31_008180) 1733457..1734323 + 867 WP_009888845.1 BRO family protein -
ITJ31_RS08185 (ITJ31_008185) 1734376..1734510 + 135 WP_009888846.1 hypothetical protein -
ITJ31_RS08190 (ITJ31_008190) 1735188..1735715 + 528 WP_009888847.1 DUF4352 domain-containing protein -
ITJ31_RS08195 (ITJ31_008195) 1735853..1736620 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1697863..1765000 67137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T282579 WP_003429855.1 NZ_CP126076:1731652-1731813 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

Antitoxin


Download         Length: 140 bp

>AT282579 NZ_CP126076:c1731872-1731733 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References