Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2856447..2856656 Replicon chromosome
Accession NZ_CP126075
Organism Clostridioides difficile strain CDI-02

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag ITJ29_RS13580 Protein ID WP_004454815.1
Coordinates 2856498..2856656 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2856447..2856581 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITJ29_RS13565 (2852338) 2852338..2853966 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
ITJ29_RS13570 (2854087) 2854087..2855082 + 996 WP_003431031.1 asparaginase -
ITJ29_RS13575 (2855271) 2855271..2855555 - 285 WP_224213953.1 BlaI/MecI/CopY family transcriptional regulator -
- (2856447) 2856447..2856581 + 135 NuclAT_0 - Antitoxin
- (2856447) 2856447..2856581 + 135 NuclAT_0 - Antitoxin
ITJ29_RS13580 (2856498) 2856498..2856656 - 159 WP_004454815.1 hypothetical protein Toxin
ITJ29_RS13585 (2857015) 2857015..2858385 - 1371 WP_021360826.1 cell wall-binding protein Cwp29 -
ITJ29_RS13590 (2858821) 2858821..2858907 + 87 WP_231298880.1 hypothetical protein -
ITJ29_RS13595 (2859437) 2859437..2859709 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
ITJ29_RS13600 (2860083) 2860083..2860163 - 81 Protein_2605 VOC family protein -
ITJ29_RS13605 (2860203) 2860203..2860871 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T282577 WP_004454815.1 NZ_CP126075:c2856656-2856498 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

Antitoxin


Download         Length: 135 bp

>AT282577 NZ_CP126075:2856447-2856581 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References