Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1525900..1526096 Replicon chromosome
Accession NZ_CP126075
Organism Clostridioides difficile strain CDI-02

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag ITJ29_RS07205 Protein ID WP_009902496.1
Coordinates 1525900..1526052 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1525996..1526096 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITJ29_RS07185 (1521439) 1521439..1521987 - 549 WP_011861206.1 DUF308 domain-containing protein -
ITJ29_RS07190 (1522139) 1522139..1522567 + 429 WP_003429356.1 DMT family transporter -
ITJ29_RS07195 (1522634) 1522634..1523302 + 669 WP_003429358.1 diphthine--ammonia ligase -
ITJ29_RS07200 (1523420) 1523420..1524775 - 1356 WP_003438549.1 MATE family efflux transporter -
ITJ29_RS07205 (1525900) 1525900..1526052 + 153 WP_009902496.1 hypothetical protein Toxin
- (1525996) 1525996..1526096 - 101 NuclAT_2 - Antitoxin
- (1525996) 1525996..1526096 - 101 NuclAT_2 - Antitoxin
ITJ29_RS07210 (1527146) 1527146..1528879 - 1734 WP_009896333.1 sensor domain-containing diguanylate cyclase -
ITJ29_RS07215 (1529119) 1529119..1529964 - 846 WP_009889222.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T282573 WP_009902496.1 NZ_CP126075:1525900-1526052 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

Antitoxin


Download         Length: 101 bp

>AT282573 NZ_CP126075:c1526096-1525996 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References