Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2764433..2764642 Replicon chromosome
Accession NZ_CP126072
Organism Clostridioides difficile strain CDI-22

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag ITI92_RS12895 Protein ID WP_004454815.1
Coordinates 2764484..2764642 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2764433..2764567 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI92_RS12880 (2759461) 2759461..2761089 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
ITI92_RS12885 (2761210) 2761210..2762205 + 996 WP_003431031.1 asparaginase -
ITI92_RS12890 (2762394) 2762394..2762678 - 285 WP_224213953.1 BlaI/MecI/CopY family transcriptional regulator -
- (2764433) 2764433..2764567 + 135 NuclAT_0 - Antitoxin
- (2764433) 2764433..2764567 + 135 NuclAT_0 - Antitoxin
ITI92_RS12895 (2764484) 2764484..2764642 - 159 WP_004454815.1 hypothetical protein Toxin
ITI92_RS12900 (2765001) 2765001..2766371 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
ITI92_RS12905 (2766807) 2766807..2766893 + 87 WP_231298880.1 hypothetical protein -
ITI92_RS12910 (2766937) 2766937..2767236 - 300 WP_225722727.1 hypothetical protein -
ITI92_RS12915 (2767423) 2767423..2767695 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
ITI92_RS12920 (2768013) 2768013..2768681 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T282569 WP_004454815.1 NZ_CP126072:c2764642-2764484 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

Antitoxin


Download         Length: 135 bp

>AT282569 NZ_CP126072:2764433-2764567 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References