Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1491947..1492143 Replicon chromosome
Accession NZ_CP126072
Organism Clostridioides difficile strain CDI-22

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag ITI92_RS06930 Protein ID WP_009902496.1
Coordinates 1491947..1492099 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1492043..1492143 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI92_RS06910 (1487486) 1487486..1488034 - 549 WP_011861206.1 DUF308 domain-containing protein -
ITI92_RS06915 (1488186) 1488186..1488614 + 429 WP_003429356.1 DMT family transporter -
ITI92_RS06920 (1488681) 1488681..1489349 + 669 WP_003429358.1 diphthine--ammonia ligase -
ITI92_RS06925 (1489467) 1489467..1490822 - 1356 WP_021359142.1 MATE family efflux transporter -
ITI92_RS06930 (1491947) 1491947..1492099 + 153 WP_009902496.1 hypothetical protein Toxin
- (1492043) 1492043..1492143 - 101 NuclAT_3 - Antitoxin
- (1492043) 1492043..1492143 - 101 NuclAT_4 - Antitoxin
ITI92_RS06935 (1493984) 1493984..1495717 - 1734 WP_021359145.1 sensor domain-containing diguanylate cyclase -
ITI92_RS06940 (1495957) 1495957..1496802 - 846 WP_009889222.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T282562 WP_009902496.1 NZ_CP126072:1491947-1492099 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

Antitoxin


Download         Length: 101 bp

>AT282562 NZ_CP126072:c1492143-1492043 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References