Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2821587..2821796 Replicon chromosome
Accession NZ_CP126071
Organism Clostridioides difficile strain CDI-23

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag ITI96_RS13075 Protein ID WP_004454815.1
Coordinates 2821638..2821796 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2821587..2821721 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI96_RS13060 (2817024) 2817024..2818652 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
ITI96_RS13065 (2818773) 2818773..2819768 + 996 WP_003431031.1 asparaginase -
ITI96_RS13070 (2819946) 2819946..2820254 - 309 WP_225532604.1 BlaI/MecI/CopY family transcriptional regulator -
- (2821587) 2821587..2821721 + 135 NuclAT_0 - Antitoxin
- (2821587) 2821587..2821721 + 135 NuclAT_0 - Antitoxin
ITI96_RS13075 (2821638) 2821638..2821796 - 159 WP_004454815.1 hypothetical protein Toxin
ITI96_RS13080 (2822090) 2822090..2823460 - 1371 WP_021373596.1 cell wall-binding protein Cwp29 -
ITI96_RS13085 (2823676) 2823676..2824491 + 816 WP_004454819.1 Arm DNA-binding domain-containing protein -
ITI96_RS13090 (2824521) 2824521..2824793 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
ITI96_RS13095 (2825156) 2825156..2825236 - 81 Protein_2504 VOC family protein -
ITI96_RS13100 (2825276) 2825276..2825944 - 669 WP_021361938.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T282560 WP_004454815.1 NZ_CP126071:c2821796-2821638 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

Antitoxin


Download         Length: 135 bp

>AT282560 NZ_CP126071:2821587-2821721 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References