Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 3704885..3705100 Replicon chromosome
Accession NZ_CP126068
Organism Clostridioides difficile strain CDI-24

Toxin (Protein)


Gene name CD0977.1 Uniprot ID Q18AH6
Locus tag ITI97_RS16945 Protein ID WP_011861054.1
Coordinates 3704957..3705100 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 3704885..3705031 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI97_RS16915 (3700108) 3700108..3700932 - 825 WP_003432350.1 phosphate ABC transporter permease PstA -
ITI97_RS16920 (3700934) 3700934..3701851 - 918 WP_021361136.1 phosphate ABC transporter permease subunit PstC -
ITI97_RS16925 (3702232) 3702232..3702705 - 474 WP_022620508.1 hypothetical protein -
ITI97_RS16930 (3703401) 3703401..3703787 - 387 WP_021366416.1 BlaI/MecI/CopY family transcriptional regulator -
ITI97_RS16935 (3703827) 3703827..3704129 - 303 Protein_3267 BlaI/MecI/CopY family transcriptional regulator -
ITI97_RS16940 (3704576) 3704576..3704752 + 177 WP_021358767.1 hypothetical protein -
- (3704885) 3704885..3705031 + 147 NuclAT_1 - Antitoxin
- (3704885) 3704885..3705035 + 151 NuclAT_0 - -
- (3704885) 3704885..3705035 + 151 NuclAT_0 - -
ITI97_RS16945 (3704957) 3704957..3705100 - 144 WP_011861054.1 hypothetical protein Toxin
ITI97_RS16950 (3705361) 3705361..3705549 + 189 WP_009898401.1 hypothetical protein -
ITI97_RS16955 (3706250) 3706250..3706771 + 522 WP_009898403.1 ImmA/IrrE family metallo-endopeptidase -
ITI97_RS16960 (3706747) 3706747..3708333 + 1587 WP_015984865.1 hypothetical protein -
ITI97_RS16965 (3708397) 3708397..3708915 - 519 WP_009898407.1 DUF5706 domain-containing protein -
ITI97_RS16970 (3709081) 3709081..3709428 - 348 WP_284180549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5337.27 Da        Isoelectric Point: 10.5719

>T282555 WP_011861054.1 NZ_CP126068:c3705100-3704957 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKLNKKQH

Download         Length: 144 bp

Antitoxin


Download         Length: 147 bp

>AT282555 NZ_CP126068:3704885-3705031 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTT
GTTTTTTATTAAGCTTGATTTTCACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q18AH6

Antitoxin

Download structure file

References