Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2824052..2824261 Replicon chromosome
Accession NZ_CP126068
Organism Clostridioides difficile strain CDI-24

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag ITI97_RS13345 Protein ID WP_004454815.1
Coordinates 2824103..2824261 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2824052..2824186 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI97_RS13330 (2819679) 2819679..2821307 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
ITI97_RS13335 (2821428) 2821428..2822423 + 996 WP_003431031.1 asparaginase -
ITI97_RS13340 (2822612) 2822612..2822896 - 285 WP_224213953.1 BlaI/MecI/CopY family transcriptional regulator -
- (2824052) 2824052..2824186 + 135 NuclAT_1 - Antitoxin
- (2824052) 2824052..2824186 + 135 NuclAT_2 - Antitoxin
ITI97_RS13345 (2824103) 2824103..2824261 - 159 WP_004454815.1 hypothetical protein Toxin
ITI97_RS13350 (2824620) 2824620..2825990 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
ITI97_RS13355 (2826426) 2826426..2826512 + 87 WP_231298880.1 hypothetical protein -
ITI97_RS13360 (2826556) 2826556..2826855 - 300 WP_231301800.1 hypothetical protein -
ITI97_RS13365 (2827042) 2827042..2827314 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
ITI97_RS13370 (2827632) 2827632..2828300 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T282553 WP_004454815.1 NZ_CP126068:c2824261-2824103 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

Antitoxin


Download         Length: 135 bp

>AT282553 NZ_CP126068:2824052-2824186 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References