Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1327537..1327742 Replicon chromosome
Accession NZ_CP126068
Organism Clostridioides difficile strain CDI-24

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag ITI97_RS06335 Protein ID WP_009896140.1
Coordinates 1327537..1327689 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1327669..1327742 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI97_RS06315 (1323477) 1323477..1323761 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
ITI97_RS06320 (1323784) 1323784..1325301 - 1518 WP_003438169.1 recombinase family protein -
ITI97_RS06325 (1325426) 1325426..1326247 - 822 WP_021367693.1 tetratricopeptide repeat protein -
ITI97_RS06330 (1326438) 1326438..1327465 + 1028 Protein_1153 cell wall-binding protein Cwp26 -
ITI97_RS06335 (1327537) 1327537..1327689 + 153 WP_009896140.1 hypothetical protein Toxin
- (1327669) 1327669..1327742 - 74 NuclAT_4 - Antitoxin
- (1327669) 1327669..1327742 - 74 NuclAT_5 - Antitoxin
ITI97_RS06340 (1329778) 1329778..1330002 - 225 WP_021367699.1 helix-turn-helix transcriptional regulator -
ITI97_RS06345 (1330681) 1330681..1330836 + 156 WP_021363414.1 hypothetical protein -
ITI97_RS06350 (1331115) 1331115..1331333 + 219 WP_009889000.1 hypothetical protein -
ITI97_RS06355 (1331990) 1331990..1332184 + 195 WP_021367700.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T282550 WP_009896140.1 NZ_CP126068:1327537-1327689 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

Antitoxin


Download         Length: 74 bp

>AT282550 NZ_CP126068:c1327742-1327669 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References