Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2775688..2775897 Replicon chromosome
Accession NZ_CP126067
Organism Clostridioides difficile strain CDI-30

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag ITI90_RS13085 Protein ID WP_004454815.1
Coordinates 2775739..2775897 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2775688..2775822 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI90_RS13070 (2771315) 2771315..2772943 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
ITI90_RS13075 (2773064) 2773064..2774059 + 996 WP_003431031.1 asparaginase -
ITI90_RS13080 (2774248) 2774248..2774532 - 285 WP_224213953.1 BlaI/MecI/CopY family transcriptional regulator -
- (2775688) 2775688..2775822 + 135 NuclAT_1 - Antitoxin
- (2775688) 2775688..2775822 + 135 NuclAT_2 - Antitoxin
ITI90_RS13085 (2775739) 2775739..2775897 - 159 WP_004454815.1 hypothetical protein Toxin
ITI90_RS13090 (2776256) 2776256..2777626 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
ITI90_RS13095 (2778062) 2778062..2778148 + 87 WP_231298880.1 hypothetical protein -
ITI90_RS13100 (2778192) 2778192..2778491 - 300 WP_231301800.1 hypothetical protein -
ITI90_RS13105 (2778678) 2778678..2778950 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
ITI90_RS13110 (2779268) 2779268..2779936 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T282548 WP_004454815.1 NZ_CP126067:c2775897-2775739 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

Antitoxin


Download         Length: 135 bp

>AT282548 NZ_CP126067:2775688-2775822 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References