Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 312124..312339 Replicon chromosome
Accession NZ_CP126067
Organism Clostridioides difficile strain CDI-30

Toxin (Protein)


Gene name CD2889 Uniprot ID Q183X5
Locus tag ITI90_RS01910 Protein ID WP_011861731.1
Coordinates 312124..312267 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 312189..312339 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITI90_RS01880 (308640) 308640..308870 + 231 WP_021364192.1 hemolysin XhlA family protein -
ITI90_RS01885 (308890) 308890..309147 + 258 WP_009898413.1 phage holin family protein -
ITI90_RS01890 (309147) 309147..309959 + 813 WP_016056343.1 N-acetylmuramoyl-L-alanine amidase -
ITI90_RS01895 (310209) 310209..310700 + 492 WP_016056344.1 hypothetical protein -
ITI90_RS01900 (310702) 310702..311268 + 567 WP_016056345.1 hypothetical protein -
ITI90_RS01905 (311678) 311678..311866 - 189 WP_009898401.1 hypothetical protein -
ITI90_RS01910 (312124) 312124..312267 + 144 WP_011861731.1 hypothetical protein Toxin
- (312189) 312189..312339 - 151 NuclAT_1 - Antitoxin
- (312193) 312193..312339 - 147 NuclAT_0 - -
- (312193) 312193..312339 - 147 NuclAT_0 - -
ITI90_RS01915 (312775) 312775..313164 + 390 WP_021376798.1 BlaI/MecI/CopY family transcriptional regulator -
ITI90_RS01920 (313258) 313258..313641 + 384 WP_021364164.1 BlaI/MecI/CopY family transcriptional regulator -
ITI90_RS01925 (314359) 314359..315750 + 1392 WP_021364166.1 metallophosphoesterase -
ITI90_RS01930 (315898) 315898..316206 - 309 WP_021364995.1 LysR substrate-binding domain-containing protein -
ITI90_RS01935 (316243) 316243..316764 + 522 WP_011860666.1 chromate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5399.34 Da        Isoelectric Point: 10.8277

>T282543 WP_011861731.1 NZ_CP126067:312124-312267 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH

Download         Length: 144 bp

Antitoxin


Download         Length: 151 bp

>AT282543 NZ_CP126067:c312339-312189 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A3R1

Antitoxin

Download structure file

References