Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 146102..146473 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name ralR Uniprot ID A0A0D6ZRD3
Locus tag QI555_RS00755 Protein ID WP_001443846.1
Coordinates 146324..146473 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 146102..146280 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS00725 (141854) 141854..142024 + 171 WP_001625136.1 protein YnaL -
QI555_RS00730 (142057) 142057..143430 + 1374 WP_000123746.1 ATP-dependent RNA helicase DbpA -
QI555_RS00735 (143559) 143559..144494 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
QI555_RS00740 (144546) 144546..145781 - 1236 WP_000040839.1 site-specific integrase -
QI555_RS00745 (145783) 145783..145998 - 216 WP_000079604.1 excisionase XisR -
- (146102) 146102..146280 + 179 NuclAT_0 - Antitoxin
- (146102) 146102..146280 + 179 NuclAT_0 - Antitoxin
- (146102) 146102..146280 + 179 NuclAT_0 - Antitoxin
- (146102) 146102..146280 + 179 NuclAT_0 - Antitoxin
QI555_RS00750 (146098) 146098..146286 - 189 WP_001302840.1 DUF1187 family protein -
QI555_RS00755 (146324) 146324..146473 - 150 WP_001443846.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
QI555_RS00760 (146529) 146529..147338 - 810 WP_000166313.1 recombination protein RecT -
QI555_RS00765 (147331) 147331..149931 - 2601 WP_000105140.1 exodeoxyribonuclease VIII -
QI555_RS00770 (150033) 150033..150308 - 276 WP_001344816.1 hypothetical protein -
QI555_RS00775 (150383) 150383..150553 - 171 WP_001352098.1 YdaE family protein -
QI555_RS00780 (150553) 150553..150774 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 144546..193698 49152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-48)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5383.12 Da        Isoelectric Point: 8.3398

>T281147 WP_001443846.1 NZ_CP124740:c146473-146324 [Escherichia coli O157:H7 str. EDL933]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Download         Length: 150 bp

Antitoxin


Download         Length: 179 bp

>AT281147 NZ_CP124740:146102-146280 [Escherichia coli O157:H7 str. EDL933]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ZRD3

Antitoxin

Download structure file

References