Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4944237..4944839 Replicon chromosome
Accession NZ_CP124429
Organism Escherichia coli strain AVS0051

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP74_RS24100 Protein ID WP_000897302.1
Coordinates 4944237..4944548 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP74_RS24105 Protein ID WP_000356397.1
Coordinates 4944549..4944839 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP74_RS24075 (4939720) 4939720..4940157 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP74_RS24080 (4940202) 4940202..4941143 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP74_RS24085 (4941207) 4941207..4942115 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP74_RS24090 (4942172) 4942172..4943392 - 1221 WP_000343765.1 ISL3-like element ISEc53 family transposase -
QJP74_RS24095 (4943411) 4943411..4943929 - 519 WP_000115885.1 ClbS/DfsB family four-helix bundle protein -
QJP74_RS24100 (4944237) 4944237..4944548 + 312 WP_000897302.1 hypothetical protein Toxin
QJP74_RS24105 (4944549) 4944549..4944839 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP74_RS24110 (4945198) 4945198..4945476 + 279 WP_001296612.1 hypothetical protein -
QJP74_RS24115 (4945873) 4945873..4946091 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP74_RS24120 (4946276) 4946276..4947016 - 741 WP_000608806.1 hypothetical protein -
QJP74_RS24125 (4947041) 4947041..4947889 - 849 WP_001038650.1 hypothetical protein -
QJP74_RS24130 (4948179) 4948179..4948421 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP74_RS24135 (4948603) 4948603..4949532 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4942172..4943392 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280236 WP_000897302.1 NZ_CP124429:4944237-4944548 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280236 WP_000356397.1 NZ_CP124429:4944549-4944839 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References