Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2894608..2895210 Replicon chromosome
Accession NZ_CP124415
Organism Escherichia coli strain AVS0223

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP60_RS14005 Protein ID WP_000897302.1
Coordinates 2894608..2894919 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP60_RS14010 Protein ID WP_000356397.1
Coordinates 2894920..2895210 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP60_RS13980 (2890091) 2890091..2890528 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP60_RS13985 (2890573) 2890573..2891514 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP60_RS13990 (2891578) 2891578..2892486 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP60_RS13995 (2892543) 2892543..2893763 - 1221 WP_000343765.1 ISL3-like element ISEc53 family transposase -
QJP60_RS14000 (2893782) 2893782..2894300 - 519 WP_000115885.1 ClbS/DfsB family four-helix bundle protein -
QJP60_RS14005 (2894608) 2894608..2894919 + 312 WP_000897302.1 hypothetical protein Toxin
QJP60_RS14010 (2894920) 2894920..2895210 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP60_RS14015 (2895569) 2895569..2895847 + 279 WP_001296612.1 hypothetical protein -
QJP60_RS14020 (2896244) 2896244..2896462 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP60_RS14025 (2896647) 2896647..2897387 - 741 WP_000608806.1 hypothetical protein -
QJP60_RS14030 (2897412) 2897412..2898260 - 849 WP_001038650.1 hypothetical protein -
QJP60_RS14035 (2898550) 2898550..2898792 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP60_RS14040 (2898974) 2898974..2899903 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2892543..2893763 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280124 WP_000897302.1 NZ_CP124415:2894608-2894919 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280124 WP_000356397.1 NZ_CP124415:2894920-2895210 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References