Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2812126..2812728 Replicon chromosome
Accession NZ_CP124405
Organism Escherichia coli strain AVS0935

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJB05_RS13560 Protein ID WP_000897302.1
Coordinates 2812126..2812437 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJB05_RS13565 Protein ID WP_000356397.1
Coordinates 2812438..2812728 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB05_RS13535 (2807609) 2807609..2808046 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJB05_RS13540 (2808091) 2808091..2809032 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJB05_RS13545 (2809096) 2809096..2810004 - 909 WP_001385591.1 alpha/beta hydrolase -
QJB05_RS13550 (2810061) 2810061..2811281 - 1221 WP_000343765.1 ISL3-like element ISEc53 family transposase -
QJB05_RS13555 (2811300) 2811300..2811818 - 519 WP_000115885.1 ClbS/DfsB family four-helix bundle protein -
QJB05_RS13560 (2812126) 2812126..2812437 + 312 WP_000897302.1 hypothetical protein Toxin
QJB05_RS13565 (2812438) 2812438..2812728 + 291 WP_000356397.1 NadS family protein Antitoxin
QJB05_RS13570 (2813087) 2813087..2813365 + 279 WP_001296612.1 hypothetical protein -
QJB05_RS13575 (2813762) 2813762..2813980 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJB05_RS13580 (2814165) 2814165..2814905 - 741 WP_000608806.1 hypothetical protein -
QJB05_RS13585 (2814930) 2814930..2815778 - 849 WP_001038650.1 hypothetical protein -
QJB05_RS13590 (2816068) 2816068..2816310 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJB05_RS13595 (2816492) 2816492..2817421 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2810061..2811281 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280055 WP_000897302.1 NZ_CP124405:2812126-2812437 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280055 WP_000356397.1 NZ_CP124405:2812438-2812728 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References