Detailed information of TA system TA279119

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3651127..3651529
• Replicon: chromosome
• Accession: NZ_CP123660
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: DE22_RS17680
• Protein ID: WP_000994223.1
• Coordinates: 3651284..3651529 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3651127..3651493 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DE22_RS17645	3646388..3646885	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
DE22_RS17650	3647646..3648350	-	705	Protein_3452	integrase core domain-containing protein	-
DE22_RS17655	3648403..3648717	+	315	WP_001539118.1	SymE family type I addiction module toxin	-
DE22_RS17660	3648783..3649061	-	279	WP_077905245.1	hypothetical protein	-
DE22_RS17665	3649378..3649845	-	468	WP_000828176.1	hypothetical protein	-
DE22_RS17670	3649842..3650213	-	372	WP_223154463.1	hypothetical protein	-
DE22_RS17675	3650717..3650950	-	234	WP_129589482.1	hypothetical protein	-
-	3651127..3651493	-	367	-	-	Antitoxin
DE22_RS17680	3651284..3651529	+	246	WP_000994223.1	hypothetical protein	Toxin
DE22_RS17685	3651593..3652039	-	447	WP_000171103.1	hypothetical protein	-
DE22_RS17690	3652036..3653535	-	1500	Protein_3460	RHS repeat-associated core domain-containing protein	-
DE22_RS17695	3653616..3653843	+	228	WP_022630712.1	SymE family type I addiction module toxin	-
DE22_RS17700	3653890..3654324	-	435	WP_000789494.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3638491..3688013	49522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T279119 WP_000994223.1 NZ_CP123660:3651284-3651529 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 367 bp

>AT279119 NZ_CP123660:c3651493-3651127 [Salmonella enterica subsp. enterica serovar Kentucky]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACTGCGCCCCCCTCTCCCCG
GCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin