Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1307184..1307409 Replicon chromosome
Accession NC_017906
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name hokW Uniprot ID A0A1Q4PF16
Locus tag CDCO157_RS06485 Protein ID WP_000813258.1
Coordinates 1307184..1307339 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1307351..1307409 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS06480 1306720..1307064 - 345 WP_000756595.1 YgiW/YdeI family stress tolerance OB fold protein -
CDCO157_RS06485 1307184..1307339 - 156 WP_000813258.1 type I toxin-antitoxin system Hok family toxin Toxin
- 1307351..1307409 + 59 - - Antitoxin
CDCO157_RS06490 1307630..1308025 - 396 WP_000426668.1 hypothetical protein -
CDCO157_RS06495 1308025..1308924 - 900 WP_014714116.1 ead/Ea22-like family protein -
CDCO157_RS06500 1308911..1309195 - 285 WP_001024844.1 DUF4752 family protein -
CDCO157_RS06505 1309192..1309413 - 222 WP_000763353.1 TraR/DksA family transcriptional regulator -
CDCO157_RS06510 1309461..1310090 - 630 WP_000203859.1 phage antirepressor Ant -
CDCO157_RS28985 1311080..1311187 + 108 WP_001273654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - stx2A / stx2B 1247081..1312598 65517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5767.95 Da        Isoelectric Point: 7.7942

>T27770 WP_000813258.1 NC_017906:c1307339-1307184 [Escherichia coli Xuzhou21]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Download         Length: 156 bp

>T27770 NC_017906:c1307339-1307184 [Escherichia coli Xuzhou21]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 59 bp

>AT27770 NC_017906:1307351-1307409 [Escherichia coli Xuzhou21]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4PF16

Antitoxin

Download structure file

References