Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4946800..4947402 Replicon chromosome
Accession NZ_CP122454
Organism Escherichia coli strain 82.0311

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QBY76_RS23980 Protein ID WP_000897302.1
Coordinates 4947091..4947402 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QBY76_RS23975 Protein ID WP_000356397.1
Coordinates 4946800..4947090 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY76_RS23950 (4942865) 4942865..4943767 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QBY76_RS23955 (4943764) 4943764..4944399 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QBY76_RS23960 (4944396) 4944396..4945325 + 930 WP_087598274.1 formate dehydrogenase accessory protein FdhE -
QBY76_RS23965 (4945549) 4945549..4945767 - 219 WP_001314326.1 CopG family transcriptional regulator -
QBY76_RS23970 (4946163) 4946163..4946441 - 279 WP_001296612.1 hypothetical protein -
QBY76_RS23975 (4946800) 4946800..4947090 - 291 WP_000356397.1 NadS family protein Antitoxin
QBY76_RS23980 (4947091) 4947091..4947402 - 312 WP_000897302.1 hypothetical protein Toxin
QBY76_RS23985 (4947639) 4947639..4948859 - 1221 WP_000343766.1 ISL3-like element ISEc53 family transposase -
QBY76_RS23990 (4948878) 4948878..4949396 - 519 WP_000115885.1 ClbS/DfsB family four-helix bundle protein -
QBY76_RS23995 (4949524) 4949524..4950432 + 909 WP_001331553.1 alpha/beta hydrolase -
QBY76_RS24000 (4950496) 4950496..4951437 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QBY76_RS24005 (4951482) 4951482..4951919 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4947639..4948859 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T276939 WP_000897302.1 NZ_CP122454:c4947402-4947091 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT276939 WP_000356397.1 NZ_CP122454:c4947090-4946800 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References