276915

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4987964..4988566 Replicon chromosome
Accession NZ_CP122451
Organism Escherichia coli strain 82.0312

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QBY78_RS24225 Protein ID WP_000897302.1
Coordinates 4988255..4988566 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QBY78_RS24220 Protein ID WP_000356397.1
Coordinates 4987964..4988254 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY78_RS24195 (4984029) 4984029..4984931 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QBY78_RS24200 (4984928) 4984928..4985563 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QBY78_RS24205 (4985560) 4985560..4986489 + 930 WP_087598274.1 formate dehydrogenase accessory protein FdhE -
QBY78_RS24210 (4986713) 4986713..4986931 - 219 WP_001314326.1 CopG family transcriptional regulator -
QBY78_RS24215 (4987327) 4987327..4987605 - 279 WP_001296612.1 hypothetical protein -
QBY78_RS24220 (4987964) 4987964..4988254 - 291 WP_000356397.1 NadS family protein Antitoxin
QBY78_RS24225 (4988255) 4988255..4988566 - 312 WP_000897302.1 hypothetical protein Toxin
QBY78_RS24230 (4988803) 4988803..4990023 - 1221 WP_000343766.1 ISL3-like element ISEc53 family transposase -
QBY78_RS24235 (4990042) 4990042..4990560 - 519 WP_000115885.1 ClbS/DfsB family four-helix bundle protein -
QBY78_RS24240 (4990688) 4990688..4991596 + 909 WP_001331553.1 alpha/beta hydrolase -
QBY78_RS24245 (4991660) 4991660..4992601 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QBY78_RS24250 (4992646) 4992646..4993083 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4988803..4990023 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T276915 WP_000897302.1 NZ_CP122451:c4988566-4988255 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT276915 WP_000356397.1 NZ_CP122451:c4988254-4987964 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References