Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 2378894..2379306 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag QCG47_RS11375 Protein ID WP_000132601.1
Coordinates 2378894..2379235 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 2379230..2379306 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS11365 (2376307) 2376307..2377353 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
QCG47_RS11370 (2377353) 2377353..2378732 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
QCG47_RS11375 (2378894) 2378894..2379235 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (2379230) 2379230..2379306 + 77 NuclAT_14 - Antitoxin
- (2379230) 2379230..2379306 + 77 NuclAT_14 - Antitoxin
- (2379230) 2379230..2379306 + 77 NuclAT_14 - Antitoxin
- (2379230) 2379230..2379306 + 77 NuclAT_14 - Antitoxin
- (2379230) 2379230..2379306 + 77 NuclAT_15 - Antitoxin
- (2379230) 2379230..2379306 + 77 NuclAT_15 - Antitoxin
- (2379230) 2379230..2379306 + 77 NuclAT_15 - Antitoxin
- (2379230) 2379230..2379306 + 77 NuclAT_15 - Antitoxin
QCG47_RS11380 (2379463) 2379463..2380857 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
QCG47_RS11385 (2380854) 2380854..2382443 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2371809..2380857 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T276758 WP_000132601.1 NZ_CP122319:c2379235-2378894 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT276758 NZ_CP122319:2379230-2379306 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References