Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 2941318..2941730 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag QCG45_RS14660 Protein ID WP_000132601.1
Coordinates 2941318..2941659 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 2941654..2941730 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS14650 (2938731) 2938731..2939777 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
QCG45_RS14655 (2939777) 2939777..2941156 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
QCG45_RS14660 (2941318) 2941318..2941659 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (2941654) 2941654..2941730 + 77 NuclAT_14 - Antitoxin
- (2941654) 2941654..2941730 + 77 NuclAT_14 - Antitoxin
- (2941654) 2941654..2941730 + 77 NuclAT_14 - Antitoxin
- (2941654) 2941654..2941730 + 77 NuclAT_14 - Antitoxin
- (2941654) 2941654..2941730 + 77 NuclAT_15 - Antitoxin
- (2941654) 2941654..2941730 + 77 NuclAT_15 - Antitoxin
- (2941654) 2941654..2941730 + 77 NuclAT_15 - Antitoxin
- (2941654) 2941654..2941730 + 77 NuclAT_15 - Antitoxin
QCG45_RS14665 (2941887) 2941887..2943281 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
QCG45_RS14670 (2943278) 2943278..2944867 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2934233..2943281 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T276738 WP_000132601.1 NZ_CP122318:c2941659-2941318 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT276738 NZ_CP122318:2941654-2941730 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References