Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 2909519..2909931 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag QCG48_RS14525 Protein ID WP_000132601.1
Coordinates 2909519..2909860 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 2909855..2909931 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS14515 (2906932) 2906932..2907978 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
QCG48_RS14520 (2907978) 2907978..2909357 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
QCG48_RS14525 (2909519) 2909519..2909860 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (2909855) 2909855..2909931 + 77 NuclAT_14 - Antitoxin
- (2909855) 2909855..2909931 + 77 NuclAT_14 - Antitoxin
- (2909855) 2909855..2909931 + 77 NuclAT_14 - Antitoxin
- (2909855) 2909855..2909931 + 77 NuclAT_14 - Antitoxin
- (2909855) 2909855..2909931 + 77 NuclAT_15 - Antitoxin
- (2909855) 2909855..2909931 + 77 NuclAT_15 - Antitoxin
- (2909855) 2909855..2909931 + 77 NuclAT_15 - Antitoxin
- (2909855) 2909855..2909931 + 77 NuclAT_15 - Antitoxin
QCG48_RS14530 (2910088) 2910088..2911482 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
QCG48_RS14535 (2911479) 2911479..2913068 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2902434..2911482 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T276676 WP_000132601.1 NZ_CP122316:c2909860-2909519 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT276676 NZ_CP122316:2909855-2909931 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References