Detailed information of TA system TA276024

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3831698..3831949
• Replicon: chromosome
• Accession: NZ_CP121189
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain S1467

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: P6164_RS18885
• Protein ID: WP_131166435.1
• Coordinates: 3831698..3831949 (+)
• Length: 84 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3831714..3831939 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P6164_RS18855	3826890..3827630	-	741	WP_051129375.1	pili assembly chaperone SafB	-
P6164_RS18860	3827705..3828202	-	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
P6164_RS18865	3828335..3828829	-	495	WP_051129373.1	hypothetical protein	-
P6164_RS18870	3829597..3830143	-	547	Protein_3698	integrase core domain-containing protein	-
P6164_RS18875	3830234..3831462	+	1229	WP_089541817.1	IS3 family transposase	-
P6164_RS18880	3831488..3831634	-	147	Protein_3700	transposase	-
P6164_RS18885	3831698..3831949	+	252	WP_131166435.1	SymE family type I addiction module toxin	Toxin
-	3831714..3831939	-	226	-	-	Antitoxin
P6164_RS18890	3831995..3832459	-	465	WP_127201574.1	hypothetical protein	-
P6164_RS18895	3832840..3833685	-	846	Protein_3703	RHS repeat-associated core domain-containing protein	-
P6164_RS18900	3833705..3833842	+	138	WP_023227287.1	hypothetical protein	-
P6164_RS18905	3833985..3834593	-	609	WP_053505599.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3810494..3856145	45651

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (10-48)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9451.82 Da
• Isoelectric Point: 8.0365

>T276024 WP_131166435.1 NZ_CP121189:3831698-3831949 [Salmonella enterica subsp. enterica serovar Indiana]
MRDTYKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVV
NGN

Nucleotide

• Length: 252 bp

Antitoxin

Nucleotide

• Length: 226 bp

>AT276024 NZ_CP121189:c3831939-3831714 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin