Detailed information of TA system TA275644

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3717146..3717560
• Replicon: chromosome
• Accession: NZ_CP121076
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain R22.3740

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: P8I06_RS18310
• Protein ID: WP_023243487.1
• Coordinates: 3717303..3717560 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3717146..3717478 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8I06_RS18280	3712399..3712962	-	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-
P8I06_RS18285	3713661..3714362	-	702	Protein_3580	integrase core domain-containing protein	-
P8I06_RS18290	3714415..3714729	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
P8I06_RS18295	3714796..3715074	-	279	WP_077677834.1	hypothetical protein	-
P8I06_RS18300	3715391..3715858	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
P8I06_RS18305	3716676..3716969	-	294	WP_039515457.1	hypothetical protein	-
-	3717146..3717478	-	333	-	-	Antitoxin
P8I06_RS18310	3717303..3717560	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
P8I06_RS18315	3717627..3717971	-	345	WP_023218822.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3695173..3740557	45384
	-	flank	IS/Tn	-	-	3713661..3713939	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T275644 WP_023243487.1 NZ_CP121076:3717303-3717560 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT275644 NZ_CP121076:c3717478-3717146 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin