Detailed information of TA system TA275608

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3717548..3717962
• Replicon: chromosome
• Accession: NZ_CP121073
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain R22.2169

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: P8I07_RS18315
• Protein ID: WP_023243487.1
• Coordinates: 3717705..3717962 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3717548..3717880 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8I07_RS18285	3712801..3713364	-	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-
P8I07_RS18290	3714063..3714764	-	702	Protein_3581	integrase core domain-containing protein	-
P8I07_RS18295	3714817..3715131	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
P8I07_RS18300	3715198..3715476	-	279	WP_077677834.1	hypothetical protein	-
P8I07_RS18305	3715793..3716260	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
P8I07_RS18310	3717078..3717371	-	294	WP_039515457.1	hypothetical protein	-
-	3717548..3717880	-	333	-	-	Antitoxin
P8I07_RS18315	3717705..3717962	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
P8I07_RS18320	3718029..3718373	-	345	WP_023218822.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3695575..3740959	45384
	-	flank	IS/Tn	-	-	3714063..3714341	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T275608 WP_023243487.1 NZ_CP121073:3717705-3717962 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT275608 NZ_CP121073:c3717880-3717548 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin