Detailed information of TA system TA275566

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3724019..3724433
• Replicon: chromosome
• Accession: NZ_CP121068
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain R21.1575

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: P8I08_RS18345
• Protein ID: WP_023243487.1
• Coordinates: 3724176..3724433 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3724019..3724351 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8I08_RS18315	3719272..3719835	-	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-
P8I08_RS18320	3720534..3721235	-	702	Protein_3587	integrase core domain-containing protein	-
P8I08_RS18325	3721288..3721602	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
P8I08_RS18330	3721669..3721947	-	279	WP_077677834.1	hypothetical protein	-
P8I08_RS18335	3722264..3722731	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
P8I08_RS18340	3723549..3723968	-	420	WP_137916409.1	hypothetical protein	-
-	3724019..3724351	-	333	-	-	Antitoxin
P8I08_RS18345	3724176..3724433	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
P8I08_RS18350	3724500..3724844	-	345	WP_023218822.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3702046..3747430	45384
	-	flank	IS/Tn	-	-	3720534..3720812	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T275566 WP_023243487.1 NZ_CP121068:3724176-3724433 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT275566 NZ_CP121068:c3724351-3724019 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin